What are the structures and events that are involved at the site where glutamate causes transmission

What are the structures and events that are involved at the site where glutamate causes transmission of an impulse between two neurons in the brain?

HOw can MK801 and memantine slow the growth of glioma?

Please help me with these questions and tell me any useful websites where I can find information because I really don't get it, and can' seem to find find anything on it in my textbook or on the internet.

What are the structures and events that are involved at the site where glutamate causes transmission...?chinese theater

This is a tough one. I'll do my best.

What are the structures and events that are involved at the site where glutamate causes transmission of an impulse between two neurons in the brain?

Glutamate is a neurotransmitter which is released from the axon terminal and binds with a surface receptor on an effector cell (such as another neuron). Astrocytes function to absorb glutamate and process by converting it to glutamine then delivering it back to the pre-synaptic cell.

Not sure the level of detail you need, but hopefully this gives you a starting point.

HOw can MK801 and memantine slow the growth of glioma?

MK801 and memantine are known glutamate antagonists, which bind with the glutamate receptor. Tumor cells in the brain (gliomas) have been found to release an excessive amount of glutamate into the brain extra-cellular matrix leading to neuronal cell death. These drugs apparently help to prevent neuronal death and possibly inhibit tumor growth by preventing glutamate release. Here is an excellent article, that I think answers your question directly and will probably be a better source for you than me:

http://www.nature.com/nm/journal/v7/n9/f...

Addition:

Also some technologies thatt could be used to study glial cancer

I would guess the most effective would be conventional methods like genetics, various imaging methods (CT scans, PET scans, MRIs).